Therapeutic Drug Monitoring AED

Antiepileptic Drug Panel.

Simultaneous quantification of 24 antiepileptic drugs from plasma or serum by LC-MS/MS for therapeutic drug monitoring.

Quick Reference
Method
LC-MS/MS
Sample Types
Plasma / Serum
Analytes

24 drugs

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What does this test assess?

This comprehensive panel enables simultaneous monitoring of 24 antiepileptic drugs, supporting optimisation of seizure control while minimising adverse effects through individualised dosing.

Clinical indications include:

  • Therapeutic drug monitoring in epilepsy
  • Assessment of medication adherence
  • Dose optimisation in polytherapy regimens
  • Monitoring during pregnancy (altered pharmacokinetics)
  • Detection of drug-drug interactions
  • Evaluation of breakthrough seizures

Measured analytes

Analyte coverage

24 antiepileptic drugs including carbamazepine, oxcarbazepine, lamotrigine, valproic acid, phenytoin, phenobarbital, levetiracetam, topiramate, lacosamide, zonisamide, clobazam, clonazepam, and others.

Analytical technique

All 24 drugs are quantified simultaneously by LC-MS/MS from a single plasma or serum sample, using stable isotope internal standards for each analyte. The method provides the specificity necessary to avoid cross-reactivity between structurally similar drugs and their metabolites.

Interested in this method?

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