All Services Pharmacotherapy Optimisation

Therapeutic Drug Monitoring.

Measurement of medication levels in blood to optimise dosing, reduce toxicity, and enhance treatment efficacy — essential for drugs with narrow therapeutic indices.

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Why TDM Matters
Efficacy Ensure drug concentrations remain within the therapeutic window
Safety Prevent toxicity from medications with narrow therapeutic indices
Individual Account for pharmacokinetic variability between patients
Compliance Verify patient adherence to prescribed medication regimens
1 Validated panel
Plasma/Serum Sample matrix
LC-MS/MS Primary platform
Expanding Methods in development
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Clinical Value

Monitoring Principles.

Narrow Therapeutic Index Critical for drugs where small dose changes cause significant efficacy or toxicity shifts
Non-Linear Kinetics Essential when drug metabolism does not follow proportional dose-response relationships
Inter-Individual Variability Accounts for genetic, age, and organ function differences affecting drug levels
Polypharmacy Monitors drug interactions when patients take multiple medications simultaneously

Drug Classes.

Antiepileptics

Carbamazepine, lamotrigine, valproic acid, phenytoin, levetiracetam, and other anticonvulsants.

Immunosuppressants

Monitoring transplant rejection prophylaxis and autoimmune therapy drug levels.

Antidepressants & Antipsychotics

Ensuring therapeutic levels for mental health medication management.

Antibiotics & Antivirals

Aminoglycosides, vancomycin, and antiviral agents requiring concentration monitoring.

Cytotoxic Agents

Chemotherapy drug level monitoring for oncology dose optimisation.

Cardiac Medications

Antiarrhythmic and cardiac glycoside therapeutic level assessment.

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Test Menu

Validated TDM Methods.

Every method is developed and clinically validated in-house — with documented sensitivity, specificity, and method-comparison data against reference standards.

Code Method Matrix Technique
AED_SPAntiepileptic drug panelPlasma/SerumLC-MS/MS