Comprehensive organic acid profiling from urine by GC-MS. Identification of over 40 inherited metabolic disorders.
40+ metabolites
3–5 working days
This method enables identification and monitoring of a broad range of inherited metabolic disorders through the detection of characteristic organic acid patterns in urine.
Clinical indications include:
Over 40 metabolites including lactic acid, citric acid cycle intermediates, fatty acid oxidation metabolites, amino acid catabolites, and neurotransmitter metabolites.
Urinary organic acids are extracted, derivatised (trimethylsilylation), and analysed by gas chromatography-mass spectrometry (GC-MS). The method provides comprehensive metabolite coverage with library-based identification of both known and unusual metabolites.
From enquiry to results — a straightforward process.
This test is available to healthcare professionals, wellness brands, clinics, and research institutions worldwide. We currently serve partners in:
Whether you need testing services for your patients, white-label kits for your brand, or method transfer to your own laboratory — get in touch to discuss how we can work together.
An organic acids test is a comprehensive metabolic screening that analyses over 200 organic acid metabolites in urine by GC-MS (gas chromatography-mass spectrometry). Organic acids are intermediary metabolic products that accumulate when specific enzyme pathways are disrupted, providing characteristic patterns that identify the underlying metabolic disorder.
The test can identify over 40 inherited metabolic disorders including propionic acidaemia, methylmalonic acidaemia, isovaleric acidaemia, glutaric aciduria types I and II, maple syrup urine disease, fatty acid oxidation disorders, and mitochondrial disorders. It is one of the most comprehensive single-test screens available for inborn errors of metabolism.
A random urine sample is collected — no special timing or preparation is required. The urine is collected using a standard collection container and shipped to our laboratory following standard protocols.
Results are typically delivered within 3 to 5 working days from the time your sample arrives at our laboratory. The analysis is performed by GC-MS, providing detailed identification and quantification of organic acid metabolites.
While both tests analyse urinary organic acids, our clinical organic acids test is focused on diagnosing inherited metabolic disorders using validated GC-MS methodology with established clinical reference ranges. It is designed for clinical and diagnostic use rather than wellness screening, and results are interpreted in the context of known metabolic disease pathways.
Masdiag's organic acids test is available worldwide through our partner network. We currently serve healthcare professionals, metabolic disease centres, and clinics in Europe, the United Kingdom, Asia, Australia, New Zealand, and the United States. Contact us to discuss testing services or method transfer.
Whether you need testing services, method transfer, or white-label kit development — we'd love to hear from you.