Research

Studies & Publications.

Our team has authored 30 peer-reviewed papers (IF 143) across metabolomics, endocrinology, toxicology, and dried blood spot diagnostics. Explore our published research and curated biomarker science below.

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Masdiag Research

Our Published Research.

30 peer-reviewed publications with a combined Impact Factor of 143 — authored or co-authored by the Masdiag laboratory team.

Vitamin D (15 papers)

Development of a Method for Multiple Vitamin D Metabolite Measurements by LC-MS/MS in Dried Blood Spots

Rola R, Kowalski K, Bieńkowski T, Kołodyńska-Goworek A, Studzińska S

Analyst, 2019; 144(1): 299–309  •  DOI →

Application of Dried Blood Spots and Serum Samples for the Determination of Vitamin D Metabolites

Rola R, Trusewicz E, Bieńkowski T, et al.

Chromatographia, 2021; 84: 695–701  •  DOI →

The Effect of a Single High Dose of Vitamin D on Serum Levels of Its Metabolites in the Elderly

Leszczyńska D, Szatko A, Kowalski K, Raczkiewicz D, Ostrowska M, Misiorowski W, Zgliczyński W, Glinicki P

Frontiers in Bioscience (Landmark), 2023; 27(10): 289  •  DOI →

Bariatric Surgery Induced Changes in Blood Cholesterol Are Modulated by Vitamin D Status

Reczkowicz J, Mika A, Antosiewicz J, Kortas J, Proczko-Stepaniak M, Śledziński T, Kowalski K, Kaska Ł

Nutrients, 2022; 14(10): 2000  •  DOI →

Fasting and Exercise Induce Changes in Serum Vitamin D Metabolites in Healthy Men

Kortas J, Kuchta A, Czerniak L, Bieńkowski T, et al.

Nutrients, 2021; 13: 1963  •  DOI →

Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation

Kortas JA, Ziemann E, Bieńkowski T, et al.

Nutrients, 2021; 13: 1280  •  DOI →

Ultra-Marathon-Induced Increase in Serum Levels of Vitamin D Metabolites: A Double-Blind Randomized Controlled Trial

Kortas JA, Ziemann E, Bieńkowski T, et al.

Nutrients, 2020; 12: 3629  •  DOI →

Vitamin D Metabolite Profile in Cholecalciferol- or Calcitriol-Supplemented Healthy and Mammary Gland Tumor-Bearing Mice

Antosiewicz J, Bieńkowski T, et al.

Nutrients, 2020; 12: 3416  •  DOI →

Improved Sample Preparation Method for Fast LC-MS/MS Analysis of Vitamin D Metabolites in Serum

Rola R, Bieńkowski T, Studzińska S

Journal of Pharmaceutical and Biomedical Analysis, 2020; 190: 113529  •  DOI →

Analysis of Vitamin D3 Metabolites in Survivors of Infantile Idiopathic Hypercalcemia Caused by CYP24A1 or SLC34A1 Mutation

Konarzewska A, Bieńkowski T, et al.

Journal of Steroid Biochemistry and Molecular Biology, 2021; 208: 105824  •  DOI →

Evaluation of Different Biological Matrices to Assess the Vitamin D Status in Newborns Using LC-MS/MS

Rola R, Bieńkowski T, et al.

Microchemical Journal, 2021; 168: 106368  •  DOI →

Vitamin D Status Including 3-epi-25(OH)D3 Among Adult Patients with Thyroid Disorders During Summer Months

Glinicki P, Bieńkowski T, et al.

Endokrynologia Polska, 2018; 69(6): 653–660  •  DOI →

Determination of Vitamin D Status in Singleton and Twin Gestations Using CLIA and LC-MS/MS

Trusewicz E, Bieńkowski T, et al.

Endocrine Connections, 2023; 12(11): e230201  •  DOI →

Diet, Sun, Physical Activity and Vitamin D Status in Children with Inflammatory Bowel Disease

Skoczeń S, Bieńkowski T, et al.

Nutrients, 2022; 14(5): 1029  •  DOI →

The Positive Impact of Vitamin D on Glucocorticoid-Dependent Skeletal Muscle Atrophy

Kortas JA, Ziemann E, Bieńkowski T, et al.

Nutrients, 2021; 13: 936  •  DOI →

Kynurenine Pathway (2 papers)

Impact of 12 Weeks of Vitamin D3 Administration in Parkinson's Patients on Kynurenine Pathway

Bytowska ZK, Korewo-Labelle D, Kowalski K, Libionka W, Przewłócka K, Kloc W, Kaczor JJ

Nutrients, 2023; 15(17): 3839  •  DOI →

Eight-Day Fasting Modulates Serum Kynurenines in Healthy Men at Rest and After Exercise

Juhas U, Reczkowicz J, Kortas JA, Żychowska M, Pilis K, Ziemann E, et al.

Frontiers in Endocrinology, 2024; 15: 1403491  •  DOI →

Amino Acids & Clinical Biomarkers (2 papers)

Plasma Amino Acids May Improve Prediction Accuracy of Cerebral Vasospasm after Aneurysmal Subarachnoid Haemorrhage

Strasser A, Bieńkowski T, et al.

Journal of Clinical Medicine, 2022; 11(2): 380  •  DOI →

Associations of Arginine with Gestational Diabetes Mellitus in a Follow-Up Study

Bieńkowski T, et al.

International Journal of Molecular Sciences, 2020; 21: 7811  •  DOI →

Coenzyme Q10 & Probiotics (3 papers)

Ubiquinone (Coenzyme Q-10) Supplementation Influences Exercise-Induced Changes in Serum 25(OH)D3

Masdiag Laboratory — Double-Blind Randomized Controlled Trial

Antioxidants, 2024; 13(7): 760  •  DOI →

Effects of Probiotics and Vitamin D3 Supplementation on Sports Performance Markers in Male Mixed Martial Arts Athletes

Przewłócka K, Bieńkowski T, et al.

International Journal of Molecular Sciences, 2023; 24(12): 10200  •  DOI →

Effects of Probiotics and Vitamin D3 Supplementation on Sports Performance Markers in Male MMA Athletes

Przewłócka K, Bieńkowski T, et al.

Sports Medicine — Open, 2023; 9(1): 31  •  DOI →

Endocrinology (4 papers)

Macro-GH — A Clinical Entity Causing a Diagnostic Challenge

Glinicki P, Bieńkowski T, et al.

Clinica Chimica Acta, 2023; 546: 117392  •  DOI →

Granin Family Peptides and INSM-1 in the Biochemical Diagnosis of Pheochromocytoma

Glinicki P, Bieńkowski T, et al.

Endocrine Abstracts, 2022; 81: RC6.5  •  DOI →

Macro-GH — A Novel Clinical Entity Causing a Diagnostic Challenge (Conference Abstract)

Glinicki P, Bieńkowski T, et al.

Endocrine Abstracts, 2022; 81: RC4.2  •  DOI →

Determination of Serum and Cord Blood Vitamin D Status in Women in Twin Pregnancies Using LC-MS/MS — Preliminary Results

Trusewicz E, Bieńkowski T, et al.

Endocrine Abstracts, 2022; 81: P93  •  DOI →

Multi-Elemental Analysis (1 papers)

Multi-Elemental Analysis of Hair and Fingernails Using ED XRF Supported by ICP-MS

Mierzyńska Z, Niemirska M, Zgonina K, Bieńkowski T, Hryniów K, Świder P, Pawlak K

Molecules, 2024; 29(4): 773  •  DOI →

Analytical Method Development (4 papers)

A Rapid and Eco-Friendly Method for Determination of Gamma-Oryzanol in Equestrian Supplements by LC-MS/MS

Rola R, Bieńkowski T, Studzińska S

Journal of Pharmaceutical and Biomedical Analysis, 2019; 172: 339–348  •  DOI →

LC-MS/MS Study of the Degradation Processes of Nitisinone and Its By-Products

Rola R, Bieńkowski T, Studzińska S

Journal of Pharmaceutical and Biomedical Analysis, 2019; 171: 15–21  •  DOI →

Determination of Free Tyrosine in Equestrian Supplements by LC-MS/MS and Comparison with Total Free Amino Acids

Rola R, Bieńkowski T, Studzińska S

Microchemical Journal, 2018; 146: 56–65  •  DOI →

LC-QqQ-MS/MS Methodology for Determination of Purine and Pyrimidine Derivatives in Unifloral Honeys

Bieńkowski T, et al.

Food Chemistry, 2021; 348: 129076  •  DOI →

Complete list of Masdiag publications. Combined Impact Factor: 143. For reprints or collaboration enquiries, please contact us.

Curated Science

Biomarker Science.

Landmark peer-reviewed research for the biomarkers we measure. These are among the most cited and influential papers in each field — a resource for partners, practitioners, and researchers.

Omega-3 & Fatty Acids

The Omega-3 Index: A New Risk Factor for Death from Coronary Heart Disease?

Harris WS, von Schacky C

Preventive Medicine, 2004; 39(1): 212–220  •  DOI →

Blood Levels of Long-Chain n–3 Fatty Acids and the Risk of Sudden Death

Albert CM, Campos H, Stampfer MJ, Ridker PM, Manson JE, Willett WC, Ma J

New England Journal of Medicine, 2002; 346(15): 1113–1118  •  DOI →

Dietary Supplementation with n-3 Polyunsaturated Fatty Acids and Vitamin E After Myocardial Infarction: GISSI-Prevenzione Trial

GISSI-Prevenzione Investigators

Lancet, 1999; 354(9177): 447–455  •  DOI →

Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease

Kris-Etherton PM, Harris WS, Appel LJ

Circulation, 2002; 106(21): 2747–2757  •  DOI →

Effects of Eicosapentaenoic Acid on Major Coronary Events in Hypercholesterolaemic Patients (JELIS)

Yokoyama M, Origasa H, Matsuzaki M, et al.

Lancet, 2007; 369(9567): 1090–1098  •  DOI →

Erythrocyte Long-Chain Omega-3 Fatty Acid Levels Are Inversely Associated with Mortality

Harris WS, et al. — The Framingham Heart Study

Journal of Clinical Lipidology, 2018; 12(3)  •  DOI →

Vitamin D

Vitamin D Deficiency

Holick MF

New England Journal of Medicine, 2007; 357(3): 266–281  •  DOI →

Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline

Holick MF, Binkley NC, Bischoff-Ferrari HA, et al.

Journal of Clinical Endocrinology & Metabolism, 2011; 96(7): 1911–1930  •  DOI →

25-Hydroxyvitamin D Levels and the Risk of Mortality in the General Population

Melamed ML, Michos ED, Post W, Astor B

Archives of Internal Medicine, 2008; 168(15): 1629–1637  •  DOI →

Vitamin D Deficiency and Risk of Cardiovascular Disease

Wang TJ, Pencina MJ, Booth SL, et al.

Circulation, 2008; 117(4): 503–511  •  DOI →

Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease (VITAL Trial)

Manson JE, Cook NR, Lee IM, et al.

New England Journal of Medicine, 2019; 380: 33–44  •  DOI →

Sunlight and Vitamin D: A Global Perspective for Health

Wacker M, Holick MF

Dermatoendocrinology, 2013; 5(1): 51–108  •  DOI →

Amino Acids & Metabolomics

A Branched-Chain Amino Acid-Related Metabolic Signature That Differentiates Obese and Lean Humans

Newgard CB, An J, Bain JR, et al.

Cell Metabolism, 2009; 10(4): 260–272  •  DOI →

Metabolite Profiles and the Risk of Developing Diabetes

Wang TJ, Larson MG, Vasan RS, et al.

Nature Medicine, 2011; 17(4): 448–453  •  DOI →

Metabolite Profiling and Cardiovascular Event Risk: A Prospective Study of 3 Population-Based Cohorts

Würtz P, Havulinna AS, Soininen P, et al.

Circulation, 2015; 131(9): 774–785  •  DOI →

Metabolomic Profiles Predict Individual Multidisease Outcomes

Menni C, Valdes AM, Visconti A, et al.

Nature Medicine, 2022; 28(11): 2309–2320  •  DOI →

Metabolomics and Metabolic Diseases: Where Do We Stand?

Newgard CB

Cell Metabolism, 2017; 25(1): 43–56  •  DOI →

Quantitative Serum NMR Metabolomics in Cardiovascular Epidemiology and Genetics

Soininen P, Kangas AJ, Würtz P, Suna T, Ala-Korpela M

Circulation: Cardiovascular Genetics, 2015; 8(1): 192–205  •  DOI →

Homocysteine

Plasma Homocysteine Levels and Mortality in Patients with Coronary Artery Disease

Nygård O, Nordrehaug JE, Refsum H, Ueland PM, et al.

New England Journal of Medicine, 1997; 337(4): 230–236  •  DOI →

Homocysteine and Cardiovascular Disease

Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham I

JAMA, 1991; 265(20): 2693–2698  •  DOI →

Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease (HOPE-2 Trial)

Lonn E, Yusuf S, Arnold MJ, et al.

New England Journal of Medicine, 2006; 354(15): 1567–1577  •  DOI →

Lowering Homocysteine in Patients with Ischemic Stroke (VISP Trial)

Toole JF, Malinow MR, Chambless LE, et al.

JAMA, 2004; 291(5): 565–575  •  DOI →

Homocysteine as a Predictive Factor for Hip Fracture in Older Persons

van Meurs JBJ, Dhonukshe-Rutten RAM, Brouwer IA, et al.

New England Journal of Medicine, 2004; 350(20): 2033–2041  •  DOI →

Total Homocysteine in Plasma or Serum: Methods and Clinical Applications

Refsum H, Smith AD, Ueland PM, et al.

Clinical Chemistry, 2004; 50(1): 3–32  •  DOI →

Glutathione

Glutathione Metabolism and Its Implications for Health

Wu G, Fang YZ, Yang S, Lupton JR, Turner ND

Journal of Nutrition, 2004; 134(3): 489–492  •  DOI →

Glutathione Metabolism and Its Selective Modification

Meister A

Journal of Biological Chemistry, 1988; 263(33): 17205–17208  •  DOI →

Glutathione and Its Role in Cellular Functions

Sies H

Free Radical Biology & Medicine, 1999; 27(9–10): 916–921  •  DOI →

Glutathione as a Marker for Human Disease

Teskey G, Abrahem R, Cao R, et al.

Advances in Clinical Chemistry, 2018; 87: 141–159  •  DOI →

Redox Status Expressed as GSH:GSSG Ratio as a Marker for Oxidative Stress in Paediatric Tumour Patients

Zitka O, Skalickova S, Galiova M, et al.

Oncology Letters, 2012; 3(5): 1091–1100  •  DOI →

Glutathione, Oxidative Stress and Aging

Dröge W

Biogerontology, 2005; 6(1): 25–37  •  DOI →

NAD+

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication During Aging

Gomes AP, Price NL, Ling AJY, et al.

Cell, 2013; 155(7): 1624–1638  •  DOI →

Transcriptional Silencing and Longevity Protein Sir2 Is an NAD-Dependent Histone Deacetylase

Imai S, Armstrong CM, Kaeberlein M, Guarente L

Nature, 2000; 403: 795–800  •  DOI →

Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+

Belenky P, Christensen KC, Gazzaniga F, et al.

Cell, 2007; 129: 473–484  •  DOI →

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

Mills KF, Yoshida S, Stein LR, et al.

Cell Metabolism, 2016; 24: 795–806  •  DOI →

Nicotinamide Mononucleotide Increases Muscle Insulin Sensitivity in Prediabetic Women

Yoshino M, Yoshino J, Kayser BD, et al.

Science, 2021; 372(6547): 1224–1229  •  DOI →

Small Molecule Activators of Sirtuins Extend Saccharomyces cerevisiae Lifespan

Howitz KT, Bitterman KJ, Cohen HY, et al.

Nature, 2003; 425: 191–196  •  DOI →

Coenzyme Q10

The Effect of Coenzyme Q10 on Morbidity and Mortality in Chronic Heart Failure: Q-SYMBIO Trial

Mortensen SA, Rosenfeldt F, Kumar A, et al.

JACC: Heart Failure, 2014; 2(6): 641–649  •  DOI →

Biochemical Rationale and Myocardial Tissue Data on the Effective Therapy of Cardiomyopathy with Coenzyme Q10

Folkers K, Vadhanavikit S, Mortensen SA

Proceedings of the National Academy of Sciences, 1985; 82(3): 901–904  •  DOI →

Response of Patients in Classes III and IV of Cardiomyopathy to Therapy with Coenzyme Q10

Langsjoen PH, Vadhanavikit S, Folkers K

Proceedings of the National Academy of Sciences, 1985; 82(12): 4240–4244  •  DOI →

Evidence of Plasma CoQ10-Lowering Effect by HMG-CoA Reductase Inhibitors

Ghirlanda G, Oradei A, Manto A, et al.

Journal of Clinical Pharmacology, 1993; 33(3): 226–229  •  DOI →

Bioenergetic and Antioxidant Properties of Coenzyme Q10: Recent Developments

Littarru GP, Tiano L

Molecular Biotechnology, 2007; 37(1): 31–37  •  DOI →

Meta-Analysis of CoQ10 Supplementation Efficacy in Heart Failure

Fotino AD, Thompson-Paul AM, Bazzano LA

American Journal of Clinical Nutrition, 2013; 97(2): 268–275  •  DOI →

Dried Blood Spot Technology

EBF Recommendation on the Validation of Bioanalytical Methods for Dried Blood Spots

Timmerman P, White S, Globig S, Lüdtke S, Brunet L, Smeraglia J

Bioanalysis, 2011; 3(14): 1567–1575  •  DOI →

The Application of Tandem Mass Spectrometry to Neonatal Screening for Inherited Disorders of Intermediary Metabolism

Chace DH, Kalas TA, Naylor EW

Annual Review of Genomics and Human Genetics, 2002; 3: 17–45  •  DOI →

Screening Newborns for Inborn Errors of Metabolism by Tandem Mass Spectrometry

Chace DH, DiPerna JC, Naylor EW

New England Journal of Medicine, 2002; 347(23): 1912–1914  •  DOI →

The Effect of Hematocrit on Bioanalysis of DBS: Results from the EBF DBS-Microsampling Consortium

Spooner N, Lad R, Barfield M

Bioanalysis, 2013; 5(17): 2119–2131  •  DOI →

Dried Blood Spots for Global Health Diagnostics and Surveillance: Opportunities and Challenges

Mei JV, Alexander JR, Adam BW, Hannon WH

American Journal of Public Health, 2001; 91(12): 1966–1967  •  DOI →

Microsampling in Pharmaceutical Bioanalysis: An Industry Perspective

Denniff P, Spooner N

Bioanalysis, 2014; 6(7): 885–895  •  DOI →